Earlier this year, three UNO students were selected to join 25 other college students from across the state to be a part of the Nebraska Institutional Development Award (IDeA) Networks of Biomedical Research Excellence program, or INBRE.
Since 2001, the program has helped expose students to professional levels of biomedical research and helped create a statewide biomedical research infrastructure bringing together undergraduate and graduate institutions to strengthen each institution’s research infrastructure and capacity to conduct cutting-edge biomedical and behavioral research.
The students, referred to as INBRE scholars, enter the program after completing their sophomore year of college upon recommendation by their college professors. The students receive a two-year scholarship and spend 10 weeks each summer conducting research on either their home campus or at the University of Nebraska Medical Center, the University of Nebraska-Lincoln or Creighton University.
This year’s group of UNO students included Timothy Rezineck, Andrew Pham and Camille Larson. The three Mavericks completed their 10-week summer program by presenting at the annual INBRE conference, where they had the opportunity to share their research with their peers and industry-leading researchers in a variety of biomedical sciences.
With the start of the Fall 2018 semester, these new INBRE scholars will join second-year scholars Zohal Alizai, Patricia Harte-Maxwell, Halee Keller and Sean Watson, to conduct biomedical research projects directed by UNO faculty.
As a bioinformatics major, Timothy Rezineck has a keen interest in understanding how analyzing large amounts of data can help us better understand ourselves and the world around us. An Omaha native, Timothy was raised on episodes of “Bill Nye: The Science Guy” and, thanks to his exposure to chemistry and enjoyment of video games in high school, he found that bioinformatics combined his interests in computers and physical science.
“The idea of discovering how things work that have been developing since before humans existed is what excites me most about science. There are bodily systems and microscopic interactions that have worked for an incredibly long time to keep us alive and we are just beginning to understand the inner workings of some of them. Discovering new things and telling others about them is incredibly exciting to me.”
Over the summer, Timothy worked with UNMC’s Shantaram Joshi, Ph.D., who specializes in cell biology and its role in the development of pediatric cancers. Timothy’s work over the summer involved how certain tumor-initiating cells are created and what new options may exist for targeted chemotherapies may be used to treat them.
Timothy says that, through INBRE, he has been able to access options he wouldn’t have otherwise had while also going to school full time.
“Programs like INBRE allow students to experience research and determine if they are interested in pursuing it as a career. With many students lacking solid financial backing, INBRE allows students to put great effort into their research, without having to suffer economically.”
When Andrew Pham initially applied for the INBRE program, he didn’t know what to expect. As a pre-med student studying at UNO, the program didn’t exactly align with his expected career path; however, he has already excelled in the program and is eager to become more involved.
Coming to UNO from LaVista, Andrew’s interest in science began at a young age and a desire to better understand the world.
“I think it's really cool how you can explain why what you see is what you see,” he says. “It's the longing for endless learning and having the impossible goal of wanting to know everything. Sometimes I think reaching for the impossible goals is more fun than the possible ones.”
Andrew, who hopes to pursue his Ph.D., is well on his way after earning second place at the INBRE conference for his oral presentation of his summer research. As the recipient of a 2018 Richard Holland Future Scientist Award, presented by the Nebraska Coalition for Lifesaving Cures, Andrew received a cash prize. Andrew was the only student from UNO to place in the Oral or Poster presentation categories.
His research, under the guidance of Paul Sorgen, Ph.D., professor of biochemistry and molecular biology at UNMC, focused on how two adjacent cells are able to form junctions that allow them to pass information from one to the other. He is also thankful for the connections he was able to make with other faculty and his college peers from across the state.
“The people I worked with over the summer definitely made the experience one I would never forget and it truly reminded me that science is a collaborative effort.”
A native of Beaver Lake, Neb., Camille Larson was inspired to pursue biology by her parents, Tim and Lisa, who are both science teachers. As part of the summer INBRE experience, Cami had the opportunity to work with Tammy L. Kielian, Ph.D., in her pathology and microbiology lab at UNMC. It was her very first time in a science lab, but it certainly won’t be her last.
“Currently, I am debating between pursuing a career in biomedical research or in physical therapy, which both involve science. My main career goal is to spend every day at work helping people, whether directly with patients in physical therapy or indirectly with new discoveries found in my research.”
While at UNMC, Cami had the opportunity to research how our bodies release ‘danger signals’ and whether they can increase risks for Staphylococcus aureus (Staph) infections.
“When people are given prosthetic joint implants, there is always a risk for infection. When a staph infection is treated and a new prosthetic is implanted the body will react to the damaged tissue by releasing Danger-Associated Molecular Patterns, or DAMPs, that increase inflammation; however we’ve notice that in more isolated examples of tissue damage the response is actually anti-inflammatory, which means bacteria can grow and spread. We want to figure out how to halt that process to keep the site from being re-infected.”
Cami recently presented a summary of her research at the INBRE annual meeting. This fall, she hopes to pursue her own research in UNO’s microbiology lab.
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